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KMID : 0811720090130060417
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Korean Journal of Physiology & Pharmacology
2009 Volume.13 No. 6 p.417 ~ p.424
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Hexane-Soluble Fraction of the Common Fig, Ficus carica, Inhibits Osteoclast Differentiation in Murine Bone Marrow-Derived Macrophages and RAW 264.7 Cells
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Park Young-Ran
Soh Yun-Jo
Choi Hwa-Jung
Kim Dae-Keun
Kim Byung-Il
Eun Jae-Soon
Cho Nam-Pyo
Moon Woo-Sung
Cho Sung-Dae
Seo Seung-Yong
Bae Tae-Sung
Nepal Manoj
Li Ri-Hua
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Abstract
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Osteoclasts, derived from multipotent myeloid progenitor cells, play homeostatic roles in skeletal modeling and remodeling, but may also destroy bone in pathological conditions such as osteoporosis and rheumatoid arthritis. Osteoclast development depends critically on a differentiation factor, the receptor activator of NF-?B ligand (RANKL). In this study, we found that the hexane soluble fraction of the common fig Ficus carica (HF6-FC) is a potent inhibitor of osteoclastogenesis in RANKL-stimulated RAW264.7 cells and in bone marrow-derived macrophages (BMMs). HF6-FC exerts its inhibitory effects by suppression of p38 and NF-?B but activation of ERK. In addition, HF6-FC significantly decreased the expression of NFATc1 and c-Fos, the master regulator of osteoclast differentiation. The data indicate that components of HF6-FC may have therapeutic effects on bone-destructive processes such as osteoporosis, rheumatoid arthritis, and periodontal bone resorption.
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KEYWORD
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Ficus carica, Osteoclast differentiation, RAW264.7 cells, Bone marrow-derived macrophages, Bone lytic diseases
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